Abstract: In order to improve the effect of unloading gas extraction by hydraulic punching drilling in low-permeability coal seams and eliminate the negative effect of punching-induced concentrated stress on gas flow, a method of enhanced gas extraction by hydraulic punching and coordinated gas injection and driving is proposed. In order to explore the factors affecting the effect of hydrofluidic punching and synergistic gas injection, a coupled flow-solid model of multi-component gas storage and transportation process was established, and the effects of different punching hole equivalent diameters, gas injection pressures, and drilling spacings on the effect of increasing gas flow and eliminating surges were analysed. The results show that increasing the equivalent diameter of punched holes can significantly increase the pressure unloading range of the coal seam, improve the effect of gas flow enhancement and shorten the period of blasting abatement. Increasing the gas injection pressure can improve the effect of gas flow enhancement, reduce the flow decay per unit time and shorten the period of blasting. Drill hole spacing does not significantly affect the effect of gas flow enhancement and blasting elimination, but the lagging phenomenon of production increase may occur when the drill hole spacing is larger. The equivalent diameter of the punched holes has a significant effect on the gas flow and content at the initial stage of gas injection; the larger the equivalent diameter is, the larger the initial gas flow is and the smaller the initial gas content is. Field engineering test results show that after adopting the synergistic gas extraction technology of hydraulic punching and gas injection in low-permeability coal seams, the maximum gas extraction flow rate of the drilled holes is increased to 0.0325 m3/min, and the flow rate is increased by 44%~85%, which has a good application effect.